6/26/2023 0 Comments Qcs 2.38Oxaliplatin (L-OHP) is a third generation of platinum-based anticancer agents with a wide spectrum of antitumor activity and lower toxicity compared to previous generations, cisplatin, and carboplatin. Conclusively, the developed AAS method could serve as a reference to investigate the pharmacokinetic behavior of total platinum in biological matrices for other L-OHP delivery systems. Thus, long-circulating liposomes prolonged L-OHP circulation time and may present a potential candidate for its tumor delivery. The results showed that the total platinum in plasma of L-OHP long-circulating liposomes displayed a biexponential pharmacokinetic profile with five folds higher bioavailability and longer distribution half-life compared to L-OHP solution. Furthermore, long-circulating liposomes were fully characterized in vitro and showed great stability when stored at 4☌ for one month. A simple and a sensitive AAS method was developed and validated to determine the total platinum originated from L-OHP liposomes in plasma. The purpose of this study was to prepare L-OHP long-circulating liposomes (L-OHP PEG lip) by reverse-phase evaporation method (REV) and investigate their pharmacokinetic behavior based on total platinum in rat plasma using atomic absorption spectrometry (AAS). Long-circulating liposomes could improve the pharmacokinetic profile of L-OHP and thus enhance its therapeutic efficacy and reduce its toxicity. The clinical efficacy of Oxaliplatin (L-OHP) is potentially limited by dose-dependent neurotoxicity and high partitioning to erythrocytes in vivo.
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